Invitrogen

IRF8 Polyclonal Antibody

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IRF8 Antibody in Western Blot (WB) — Western blot analysis of IRF8 in Lane 1: RAJI cell lysate, Lane 2: rat liver tissue lysate, Lane 3: rat kidney tissue lysate. Samples were incubated with IRF8 polyclonal antibody (Product # PA5-95155).

Product Details

PA5-95155

Applications	Tested Dilution	Publications
Western Blot (WB)	0.1-0.5 µg/mL	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human IRF8 (411-426aa ASHQRSFFRENQQITV). View immunogen
Conjugate	Unconjugated
Form	Lyophilized
Concentration	500 µg/mL
Purification	Affinity chromatography
Storage buffer	PBS with 5mg BSA
Contains	0.05mg sodium azide, 0.05mg thimerosal
Storage conditions	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID	AB_2806960

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: H-ICSBP; ICSBP; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; IRF-8; transcription factor ICSBP

Gene Aliases: AI893568; H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B; IRF-8; IRF8; Myls

UniProt ID: (Human) Q02556, (Mouse) P23611

Entrez Gene ID: (Human) 3394, (Rat) 292060, (Mouse) 15900

Molecular Function: winged helix/forkhead transcription factor