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IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.
Protein Aliases: 160 kDa phosphotyrosine protein; Insulin receptor substrate 4; IRS-4; Phosphoprotein of 160 kDa; pp160; py160; RP23-415G1.3
Gene Aliases: IRS-4; IRS4; PY160
UniProt ID: (Human) O14654
Entrez Gene ID: (Human) 8471