PA5-30470 targets ISCU in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-30470 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 167 of Human ISCU.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.
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Protein Aliases: 2310020H20Rik; HML; hnifU; iron-sulfur cluster assembly enzyme ISCU; Iron-sulfur cluster assembly enzyme ISCU, mitochondrial; IscU iron-sulfur cluster scaffold homolog; ISU2; mitochondrial; NIFU; NifU-like N-terminal domain containing; NifU-like N-terminal domain-containing protein; NifU-like protein; NIFUN
Gene Aliases: 2310020H20Rik; HML; hnifU; ISCU; ISU2; NIFU; NIFUN
UniProt ID: (Human) Q9H1K1
Entrez Gene ID: (Human) 23479