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Product Details
PA5-119571
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Islet 2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913144
Product Specific Information
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Target Information
ISL LIM Homeobox 2 (ISL2) is a gene located on chromosome 15q23 that encodes a transcription factor belonging to the LIM-homeodomain family. These transcription factors play critical roles in the regulation of gene expression during embryonic development, particularly in the differentiation and maintenance of neuronal and pancreatic cell lineages. ISL2 is specifically involved in the development of the nervous system, where it contributes to motor neuron differentiation and connectivity, as well as in the development of certain retinal structures. The protein functions by binding to specific DNA sequences, thereby influencing the transcription of target genes essential for cellular differentiation and identity. Although less studied than its paralog ISL1, ISL2's expression and roles in developmental pathways are crucial for proper organogenesis and tissue specification. Dysregulation of ISL2 has potential implications in developmental disorders and diseases involving neural and pancreatic tissues. Ongoing research aims to further elucidate its functions and potential as a therapeutic target in developmental biology and disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Insulin gene enhancer protein ISL-2; ISL2 transcription factor, LIM/homeodomain, (islet-2); islet 2; Islet-2
Gene Aliases: 3110001N10Rik; ISL2
UniProt ID: (Human) Q96A47, (Mouse) Q9CXV0
Entrez Gene ID: (Human) 64843, (Mouse) 104360
regulation of transcription, DNA-templated
multicellular organism development
spinal cord motor neuron cell fate specification
visceral motor neuron differentiation
retinal ganglion cell axon guidance
negative regulation of neuron differentiation
neuron fate commitment
neuron development
peripheral nervous system neuron development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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