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Invitrogen
ISL2 Polyclonal Antibody
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FIGURE: 1 / 1
ISL2 Antibody (PA5-47599) in WB
Western blot analysis of ISL2 in HUVEC human umbilical vein endothelial cells. Samples were incubated in ISL2 polyclonal antibody (Product # PA5-47599) using a dilution of 1 µg/mL followed by a HRP-conjugated Anti-Sheep IgG secondary antibody. A specific band was detected for Islet‚2 at approximately 42 kDa (as indicated). This experiment was conducted under reducing conditions.
Product Details
PA5-47599
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human Islet-2 Met1-Thr359
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
ISL LIM Homeobox 2 (ISL2) is a gene located on chromosome 15q23 that encodes a transcription factor belonging to the LIM-homeodomain family. These transcription factors play critical roles in the regulation of gene expression during embryonic development, particularly in the differentiation and maintenance of neuronal and pancreatic cell lineages. ISL2 is specifically involved in the development of the nervous system, where it contributes to motor neuron differentiation and connectivity, as well as in the development of certain retinal structures. The protein functions by binding to specific DNA sequences, thereby influencing the transcription of target genes essential for cellular differentiation and identity. Although less studied than its paralog ISL1, ISL2's expression and roles in developmental pathways are crucial for proper organogenesis and tissue specification. Dysregulation of ISL2 has potential implications in developmental disorders and diseases involving neural and pancreatic tissues. Ongoing research aims to further elucidate its functions and potential as a therapeutic target in developmental biology and disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Insulin gene enhancer protein ISL-2; ISL2 transcription factor, LIM/homeodomain, (islet-2); Islet-2; unnamed protein product
Gene Aliases: ISL2
UniProt ID: (Human) Q96A47
Entrez Gene ID: (Human) 64843
regulation of transcription, DNA-templated
axonogenesis
spinal cord motor neuron cell fate specification
visceral motor neuron differentiation
neuron differentiation
retinal ganglion cell axon guidance
negative regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
neuron fate commitment
neuron fate specification
neuron development
peripheral nervous system neuron development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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