Invitrogen

ITGA2 Recombinant Rabbit Monoclonal Antibody (ARC0457)

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ITGA2 Antibody in Immunohistochemistry (IHC) — Immunohistochemical analysis of ITGA2 performed on paraffin embedded human colon carcinoma using a ITGA2 monoclonal antibody (Product # MA5-35243) at a dilution of 1:100. An HRP Goat Anti-Rabbit IgG (H+L) secondary antibody was applied at a dilution of 1:10,000.

ITGA2 Antibody in Western Blot (WB) — Western Blot analysis of ITGA2 performed on various cell lines using a ITGA2 monoclonal antibody (Product # MA5-35243) at a dilution of 1:1,000. An HRP Goat Anti-Rabbit IgG (H+L) secondary antibody was applied at a dilution of 1:10,000.

Product Details

MA5-35243

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 1 publication 1 publication
Immunohistochemistry (IHC)	1:50-1:200	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human
Host/Isotype	Rabbit / IgG
Class	Recombinant Monoclonal
Type	Antibody
Clone	ARC0457
Immunogen	A synthesized peptide derived from human Integrin alpha 2
Conjugate	Unconjugated
Form	Liquid
Concentration	0.45 mg/mL
Purification	Protein A
Storage buffer	PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains	0.02% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2849146

Target Information

CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Global miRNA/proteomic analyses identify miRNAs at 14q32 and 3p21, which contribute to features of chronic iron-exposed fallopian tube epithelial cells.

Scientific reports

Chhabra R,Rockfield S,Guergues J,Nadeau OW,Hill R,Stevens SM,Nanjundan M

MA5-35243 was used in Western Blot to identify global miRNA and protein alterations in fallopian tube secretory epithelial cells during process of malignant transformation.

Thu Mar 18 00:00:00 EDT 2021

Global miRNA/proteomic analyses identify miRNAs at 14q32 and 3p21, which contribute to features of chronic iron-exposed fallopian tube epithelial cells.

Scientific reports

Chhabra R,Rockfield S,Guergues J,Nadeau OW,Hill R,Stevens SM,Nanjundan M

MA5-35243 was used in Western Blot to identify global miRNA and protein alterations in fallopian tube secretory epithelial cells during process of malignant transformation.

Thu Mar 18 00:00:00 EDT 2021

Bioinformatics

Protein Aliases: alpha 2 subunit of VLA-2 receptor; BDPLT9; CD49 antigen-like family member B; CD49b; Collagen receptor; GPIa; human platelet alloantigen system 5; Integrin alpha-2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); platelet antigen Br; platelet glycoprotein GPIa; Platelet membrane glycoprotein Ia; very late activation protein 2 receptor, alpha-2 subunit; VLA-2 receptor, alpha 2 subunit; VLA-2 subunit alpha; VLA2 receptor

Gene Aliases: BR; CD49B; DX5; GPIa; HPA-5; ITGA2; VLA-2; VLAA2

UniProt ID: (Human) P17301, (Mouse) Q62469

Entrez Gene ID: (Human) 3673, (Mouse) 16398, (Rat) 170921

Molecular Function: integrin