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Invitrogen
ITGA3 Polyclonal Antibody
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Product Details
PA5-33859
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 18 amino acid peptide from internal region of human ITGA3 / CD49c.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Monkey (100%) Gibbon, Galago, Hamster, Elephant, Rabbit, Guinea pig (94%).
Target Information
ITGA3 (INTEGRIN, ALPHA-3), also called CD49C, VLA3 or GAPB3, is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit which is also a member of the family of cell surface adhesion molecules. ITGA3 is mapped to chromosome 17 and its exact cytogenetic location is 17q21.33. ITGA3 makes up half of the alpha3beta1 integrin duplex that plays a role in neural migration and corticogenesis together with beta-1 subunit. A functional link between DAB1 phosphorylation and ITGA3 signaling drives the timely detachment of migrating neurons from radial glial fibers. Expression of human ITGA3 increased the infectivity of virus for Chinese hamster ovary cells. ITGA3 also contains 13 potential N-glycosylation sites, 2 potential cleavage sites, and the 7 N-terminal repeating units characteristic of ITGAs. Recombinant ITGA3 is expressed as a 150-kD protein as the same size as the native protein by the western blot analysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha 3 subunit of VLA-3 receptor; Alpha3 integrin; antigen CD49C; antigen identified by monoclonal antibody J143; CD49 antigen-like family member C; CD49c; CD49c antigen; FLJ34631; FLJ34704; FRP-2; Galactoprotein B3; GAPB3; integrin alpha 3; Integrin alpha-3; Integrin alpha3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); testicular tissue protein Li 96; testicular tissue protein Li 98; very late activation protein 3 receptor, alpha-3 subunit; VLA-3 subunit alpha
Gene Aliases: CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; ITGA3; MSK18; VCA-2; VL3A; VLA3a
UniProt ID: (Human) P26006
Entrez Gene ID: (Human) 3675
neuron migration
cell-matrix adhesion
integrin-mediated signaling pathway
heart development
memory
positive regulation of gene expression
positive regulation of epithelial cell migration
positive regulation of cell-substrate adhesion
positive regulation of neuron projection development
regulation of transforming growth factor beta receptor signaling pathway
regulation of Wnt signaling pathway
extracellular matrix organization
lung development
regulation of BMP signaling pathway
negative regulation of cell projection organization
response to gonadotropin
negative regulation of Rho protein signal transduction
exploration behavior
response to drug
skin development
mesodermal cell differentiation
leukocyte migration
maternal process involved in female pregnancy
nephron development
positive regulation of establishment of protein localization to plasma membrane
dendritic spine maintenance
renal filtration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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