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ITGA5 Antibody (711210) in WB
Western blot analysis was performed on Membrane enriched cell extracts (30 µg lysate) of U-87 MG (Lane 1), A-431 (Lane 2), U-937 (Lane 3), THP-1 (Lane 4), HeLa (Lane 5) and Tissue lysates of Mouse Heart (Lane 6) and Rat Heart (Lane 7). The blots were probed with Anti-Integrin alpha 5 beta 1 Recombinant Rabbit Superclonal™ Antibody (Product # 711210, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). A 160 kDa ban... View More
Product Details
711210
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Superclonal
Type
Antibody
Immunogen
Protein corresponding to Human ITGA5 (aa 800-1050)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Monkey, Horse, Cat and Bovine
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
Target Information
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD49 antigen-like family member E; CD49e; fibronectin receptor alpha polypeptide; Fibronectin receptor subunit alpha; fibronectin receptor, alpha polypeptide; fibronectin receptor, alpha subunit; integrin alpha 5 (fibronectin receptor alpha); Integrin alpha-5; Integrin alpha-F; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); ITGA5/SLC9B1 fusion; surface glycoprotein receptor; unnamed protein product; very late activation protein 5, alpha subunit; VLA-5
Gene Aliases: CD49e; FNRA; ITGA5; Itga5_retired; VLA-5; VLA5; VLA5A
UniProt ID: (Human) P08648, (Mouse) P11688
Entrez Gene ID: (Human) 3678, (Mouse) 16402, (Rat) 315346
virus receptor activity
receptor binding
epidermal growth factor receptor binding
platelet-derived growth factor receptor binding
integrin binding
calcium ion binding
protein binding
signaling receptor activity
vascular endothelial growth factor receptor 2 binding
metal ion binding
cell adhesion molecule binding
receptor activity
integrin
angiogenesis
formation of primary germ layer
cell-substrate junction assembly
cell adhesion
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
female pregnancy
memory
tissue development
positive regulation of cell-substrate adhesion
response to muscle activity
CD40 signaling pathway
positive regulation of cell migration
positive regulation of vascular endothelial growth factor receptor signaling pathway
cell-substrate adhesion
cell adhesion mediated by integrin
cell-cell adhesion mediated by integrin
heterotypic cell-cell adhesion
wound healing, spreading of epidermal cells
endodermal cell differentiation
regulation of angiogenesis
viral entry into host cell
cell-cell adhesion
positive regulation of vascular endothelial growth factor signaling pathway
positive regulation of sprouting angiogenesis
negative regulation of anoikis
positive regulation of peptidyl-tyrosine phosphorylation
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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