Sequence of this protein is as follows: LPEGVANGIE VYSTKINSKV TSRFAHNVVT MRAVNRADTA KEVSFDVELP KTAFITNFTL TIDGVTYPGN VKEKEVAKKQ YEKAVSQGKT AGLVKASGRK LEKFTVSVNV AAGSKVTFEL TYEELLKRHK GKYEMYLKVQ PKQLVK
This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. Polymorphisms of this gene may be associated with increased risk for schizophrenia and major depressive disorder. This gene is present in an inter-alpha-trypsin inhibitor family gene cluster on chromosome 3.
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Protein Aliases: inter-alpha (globulin) inhibitor H3; inter-alpha (globulin) inhibitor, H3 polypeptide; inter-alpha-inhibitor H3 chain; inter-alpha-inhibitor heavy chain 3; Inter-alpha-trypsin inhibitor heavy chain H3; ITI heavy chain H3; ITI-HC3; pre-alpha (globulin) inhibitor, H3 polypeptide; pre-alpha-inhibitor heavy chain 3; pre-alpha-inhibitor, heavy chain 3; Serum-derived hyaluronan-associated protein; SHAP
Gene Aliases: AW108094; H3P; Intin3; ITI-HC3; Itih-3; ITIH3; PAIHC3; SHAP