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Product Details
PA5-21883
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:3,000 | - |
Immunocytochemistry (ICC/IF) |
1:100-1:1,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fragment corresponding to a region within amino acids 171 and 414 of ITPK1 (Uniprot ID#Q13572) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.53 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
0.1M tris glycine, pH 7, with 10% glycerol |
Contains |
0.01% thimerosal |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_11153702 |
Product Specific Information
Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji, mouse brain.
Predicted reactivity: Mouse (87%), Rat (86%), Pig (87%), Bovine (86%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ITPK1 encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Inositol 1,3,4-trisphosphate 5/6-kinase; Inositol-tetrakisphosphate 1-kinase; Inositol-triphosphate 5/6-kinase; ins(1,3,4)P(3) 5/6-kinase
Gene Aliases: BC031182; ITPK1; ITRPK1
UniProt ID: (Human) Q13572, (Mouse) Q8BYN3
Entrez Gene ID: (Human) 3705, (Mouse) 217837
Molecular Function:
kinase
magnesium ion binding
catalytic activity
ATP binding
isomerase activity
inositol tetrakisphosphate 1-kinase activity
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
inositol-1,3,4-trisphosphate 6-kinase activity
inositol-1,3,4-trisphosphate 5-kinase activity
inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity
inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity
inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity
inositol-3,4,6-trisphosphate 1-kinase activity
nucleotide binding
kinase activity
transferase activity
hydrolase activity
metal ion binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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