Immunogen sequence: DGSCSTDFKT TRSREQVLRV FEEFVQGDEE VLRRYLNRLQ QIRDTLEVSE FFRRHEV
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 89%.
Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.
Protein Aliases: EC 184.108.40.206; Inositol 1,4,5-trisphosphate 3-kinase A; Inositol-trisphosphate 3-kinase A; insP 3-kinase A; IP3 3 kinase A; IP3 3-kinase A; IP3-kinase A; IP3K A
Gene Aliases: IP3-3KA; IP3KA; ITPKA
Molecular Function: kinase