Immunogen sequence: PDKPFLRKAC SPSNIPAVII TDMGTQEDGA LEETQGSPRG NLPLRKLSSS SASSTGFSSS YEDSEEDISS DPE
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 82%.
Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) regulates the level of calcium within the cell by releasing calcium from intracellular stores. Ins(1,4,5)P3 is phosphorylated by inositol 1,4,5-trisphosphate 3-kinase (IP3K) to form inositol 1,3,4,5-tetrakisphosphate (Ins(1,4,5)P4), which is is thought to regulate the influx of calcium across the plasma membrane. IP3K exists as three isoforms, IP3KA, B, and C. IP3KA, the most highly characterized isoform, is expressed in rat brain and testis. IP3KB is expressed in various rat tissues such as lung, thymus, testis, brain, and heart. IP3K activity is stimulated in the presence of calmodulin via phosphorylation by cAMP-dependent protein kinase, protein kinase C, or calcium/calmodulin dependent protein kinase II and, subsequently, mediates the inositol phosphate signaling pathways.
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Protein Aliases: 4; 5-trisphosphate 3-kinase B; Inositol 1; Inositol 1,4,5-trisphosphate 3-kinase B; Inositol-trisphosphate 3-kinase B; InsP 3-kinase B; IP3 3-kinase B; IP3K B; IP3KB; proliferation-inducing protein 37
Gene Aliases: IP3-3KB; IP3K; IP3K-B; IP3KB; ITPKB; PIG37
UniProt ID: (Human) Q96BZ2
Entrez Gene ID: (Human) 3707