Proteintech

ITPR1 Polyclonal Antibody

Tech Support

Datasheet

Protocols

Questions & Answers

Tech Support

Antibody Testing Data (8)

ITPR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 8

ITPR1 Antibody (19962-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human brain tissue slide using 19962-1-AP ( ITPR1-specific antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

ITPR1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

19962-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.49 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The antibody has no cross reaction with ITPR2 and ITPR3.

Target Information

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Estrogen receptor subtype mediated anti-inflammation and vasorelaxation via genomic and nongenomic actions in septic mice.

Frontiers in endocrinology

Zhang L,Wan H,Zhang M,Lu W,Xu F,Dong H

Mon Jun 05 00:00:00 EDT 2023

Intracellular Calcium Overload and Activation of CaMKK/AMPK Signaling Are Related to the Acceleration of Muscle Glycolysis of Broiler Chickens Subjected to Acute Stress.

Journal of agricultural and food chemistry

Liao H,Zhang L,Li J,Xing T,Gao F

Wed Mar 08 00:00:00 EST 2023

Crosstalk between Mfn2-mediated mitochondria associated membranes disorder and autophagy induced by molybdenum and cadmium in sheep heart.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Peng C,Yang S,Yang F,Xiong Z,Liu Q,Liao S,Huang K,Wan W,Cao H

Sat Apr 01 00:00:00 EDT 2023

Transient Receptor Potential Vanilloid Type 1 Protects Against Pressure Overload-Induced Cardiac Hypertrophy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes.

Journal of cardiovascular pharmacology

Wang Y,Li X,Xu X,Qu X,Yang Y

Thu Sep 01 00:00:00 EDT 2022

Transient Receptor Potential Vanilloid Type 1 Protects Against Pressure Overload-Induced Cardiac Hypertrophy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes.

Journal of cardiovascular pharmacology

Wang Y,Li X,Xu X,Qu X,Yang Y

Thu Sep 01 00:00:00 EDT 2022

Systematic analysis of the expression and prognostic value of ITPR1 and correlation with tumor infiltrating immune cells in breast cancer.

BMC cancer

Han B,Zhen F,Zheng XS,Hu J,Chen XS

Mon Mar 21 00:00:00 EDT 2022

Systematic analysis of the expression and prognostic value of ITPR1 and correlation with tumor infiltrating immune cells in breast cancer.

BMC cancer

Han B,Zhen F,Zheng XS,Hu J,Chen XS

Mon Mar 21 00:00:00 EDT 2022

A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling.

Molecular psychiatry

Qin Y,Du Y,Chen L,Liu Y,Xu W,Liu Y,Li Y,Leng J,Wang Y,Zhang XY,Feng J,Zhang F,Jin L,Qiu Z,Gong X,Wang H

Fri Jul 01 00:00:00 EDT 2022

MORTALIN-Ca²⁺ axis drives innate rituximab resistance in diffuse large B-cell lymphoma.

Cancer letters

Sun Q,Ye Y,Gui A,Sun X,Xie S,Zhan Y,Chen R,Yan Y,Gu J,Qiu S,Liu W,Zuo J,Zhang Q,Yang L

Fri Jul 01 00:00:00 EDT 2022

PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.

Diabetes

Li C,Li L,Yang M,Yang J,Zhao C,Han Y,Zhao H,Jiang N,Wei L,Xiao Y,Liu Y,Xiong X,Xi Y,Luo S,Deng F,Chen W,Yuan S,Zhu X,Xiao L,Sun L

Sun May 01 00:00:00 EDT 2022

Interleukin-6-Mediated-Ca²⁺ Handling Abnormalities Contributes to Atrial Fibrillation in Sterile Pericarditis Rats.

Frontiers in immunology

Liao J,Zhang S,Yang S,Lu Y,Lu K,Wu Y,Wu Q,Zhao N,Dong Q,Chen L,Du Y

Mon Feb 14 00:00:00 EST 2022

Prenatal hypoxia induced ET_BR activation and abnormal ROS signalling in pulmonary artery cells of rat offspring.

Reproductive toxicology (Elmsford, N.Y.)

Zhang Y,Tang J,Li N,Tao J,Zhang Y,Zhang Y,Ye Y,Zheng Q,Xu T,Liu Y,Zhang P,Li L,Li H,He Y,Su H,He Q,Sun M,Xu Z

Fri Oct 01 00:00:00 EDT 2021

MAMs Protect Against Ectopic Fat Deposition and Lipid-Related Kidney Damage in DN Patients.

Frontiers in endocrinology

Yang M,Han Y,Luo S,Xiong X,Zhu X,Zhao H,Jiang N,Xiao Y,Wei L,Li C,Yang J,Sun L

Mon Dec 20 00:00:00 EST 2021

Sulforaphane Balances Ca²⁺ Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).

Molecular nutrition & food research

Tian S,Lei P,Zhang J,Sun Y,Li B,Shan Y

Thu Jul 01 00:00:00 EDT 2021

ITPR3 facilitates tumor growth, metastasis and stemness by inducing the NF-ĸB/CD44 pathway in urinary bladder carcinoma.

Journal of experimental & clinical cancer research : CR

Zhang M,Wang L,Yue Y,Zhang L,Liu T,Jing M,Liang X,Ma M,Xu S,Wang K,Wang X,Fan J

Thu Feb 11 00:00:00 EST 2021

Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7.

Neuron

Stoyas CA,Bushart DD,Switonski PM,Ward JM,Alaghatta A,Tang MB,Niu C,Wadhwa M,Huang H,Savchenko A,Gariani K,Xie F,Delaney JR,Gaasterland T,Auwerx J,Shakkottai VG,La Spada AR

Wed Feb 19 00:00:00 EST 2020

Label-Free Quantitative Proteomic Profiling of LAD2 Mast Cell Releasates Reveals the Mechanism of Tween-80-Induced Anaphylactoid Reaction.

Proteomics. Clinical applications

Mi YN,Yan PP,Di J,Cao L,Xiao X,Liu DZ,Cao YX

Wed Jul 01 00:00:00 EDT 2020

DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity.

EBioMedicine

Yang M,Zhao L,Gao P,Zhu X,Han Y,Chen X,Li L,Xiao Y,Wei L,Li C,Xiao L,Yuan S,Liu F,Dong LQ,Kanwar YS,Sun L

Wed May 01 00:00:00 EDT 2019

Memantine can improve chronic ethanol exposure-induced spatial memory impairment in male C57BL/6 mice by reducing hippocampal apoptosis.

Toxicology

Wang X,Yu H,You J,Wang C,Feng C,Liu Z,Li Y,Wei R,Xu S,Zhao R,Wu X,Zhang G

Wed Aug 01 00:00:00 EDT 2018

Memantine can improve chronic ethanol exposure-induced spatial memory impairment in male C57BL/6 mice by reducing hippocampal apoptosis.

Toxicology

Wang X,Yu H,You J,Wang C,Feng C,Liu Z,Li Y,Wei R,Xu S,Zhao R,Wu X,Zhang G

Wed Aug 01 00:00:00 EDT 2018

Memantine Can Reduce Ethanol-Induced Caspase-3 Activity and Apoptosis in H4 Cells by Decreasing Intracellular Calcium.

Journal of molecular neuroscience : MN

Wang X,Chen J,Wang H,Yu H,Wang C,You J,Wang P,Feng C,Xu G,Wu X,Zhao R,Zhang G

Tue Aug 01 00:00:00 EDT 2017

Memantine Can Reduce Ethanol-Induced Caspase-3 Activity and Apoptosis in H4 Cells by Decreasing Intracellular Calcium.

Journal of molecular neuroscience : MN

Wang X,Chen J,Wang H,Yu H,Wang C,You J,Wang P,Feng C,Xu G,Wu X,Zhao R,Zhang G

Tue Aug 01 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: Inositol 1,4,5 trisphosphate receptor; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor; Inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate receptor, type 1; Inositol 1,4,5-trisphosphate-binding protein P400; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; InsP3R type I; insP3R1; InsP>3

View more View less

Gene Aliases: ACV; CLA4; D6Pas2; ENSMUSG00000072853; Gm10429; I145TR; InsP3R; INSP3R1; IP3R; IP3R1; Itpr-1; ITPR1; opt; P400; Pcd6; Pcp-1; Pcp1; PPP1R94; SCA15; SCA16; SCA29

View more View less

UniProt ID: (Human) Q14643, (Mouse) P11881, (Rat) P29994

View more View less

Entrez Gene ID: (Human) 3708, (Mouse) 16438, (Rat) 25262

View more View less

Function(s)

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity protein binding calcium ion transmembrane transporter activity calcium-release channel activity calcium channel inhibitor activity phosphatidylinositol binding ion channel activity calcium channel activity protein C-terminus binding protein phosphatase binding protein complex binding ligand-gated ion channel

Process(es)

response to hypoxia calcium ion transport signal transduction post-embryonic development regulation of autophagy platelet activation endoplasmic reticulum calcium ion homeostasis epithelial fluid transport inositol phosphate-mediated signaling regulation of insulin secretion negative regulation of calcium-mediated signaling voluntary musculoskeletal movement release of sequestered calcium ion into cytosol intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of cardiac conduction transport ion transport apoptotic process positive regulation of cytosolic calcium ion concentration positive regulation of calcium ion transport transmembrane transport calcium ion transmembrane transport cellular response to cAMP negative regulation of neuron death cellular response to hypoxia

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

ITPR1 Polyclonal Antibody

ITPR1 Antibody (19962-1-AP) in IHC (P)

Product Details

19962-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!