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| Applications | Tested Dilution | Publications |
|---|---|---|
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic peptide corresponding to a region derived from internal residues of human inositol 1,4,5-trisphosphate receptor, type 3 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
2.7 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 40% glycerol |
Contains |
0.05% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2636140 |
The antibody detects endogenous levels of total ITPR3 protein.
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: inositol 1,4,5-triphosphate receptor, type 3; Inositol 1,4,5-trisphosphate receptor type 3; inositol 1,4,5-trisphosphate receptor, type 3; insP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R 3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor
Gene Aliases: IP3R; IP3R3; ITPR3
UniProt ID: (Human) Q14573
Entrez Gene ID: (Human) 3710
Molecular Function:
ligand-gated ion channel
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