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Invitrogen
ITPRIPL1 Polyclonal Antibody
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Product Details
PA5-53692
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ITPRIPL1
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
Immunogen sequence: PVTSYNWLTD FPSQEALDSF YKHYVQNAIR DLPCTCEFVE SFVDDLIEAC RVLSRQEAHP QLEDCLGIGA AFEKWGTLHE TQKFDILVPI VPPQGTMFVL EMRDPALGRR CGCVLVESEC VCKREKLLGD VL
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 90%.
Target Information
The ITPRIPL1 (Inositol 1,4,5-Trisphosphate Receptor Interacting Protein-Like 1) gene encodes a protein implicated in T cell regulation by interacting with the CD3ε molecule. It is located on chromosome 6. The ITPRIPL1 protein acts as an inhibitory ligand for CD3ε, thereby modulating T cell activation in the tumor microenvironment. This interaction significantly reduces calcium influx and phosphorylation of ZAP70, which are critical steps in the T cell activation pathway. The downregulation of these processes by ITPRIPL1 suggests its role in immune response modulation and tumor immune evasion. Given its regulatory functions, ITPRIPL1 has become a subject of research for its potential implications in cancer immunotherapy and as a biomarker for diagnosing and prognosticating various cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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