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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 415 and 640 of Human IVNS1ABP|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-31277 targets IVNS1ABP in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-31277 immunogen is recombinant fragment corresponding to a region within amino acids 415 and 640 of Human IVNS1ABP.
Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
aryl hydrocarbon receptor-associated 3; aryl hydrocarbon receptor-associated protein 3; FLARA3; HSPC068; influenza virus NS1A-binding protein; influenza virus NS1A-binding protein homolog; kelch family protein Nd1; kelch family protein Nd1-L; kelch-like family member 39; KLHL39; NCX downstream gene 1; ND1; ND1-L2; NS-1; NS1-binding protein; NS1-binding protein homolog; NS1BP
1190004M08Rik; 1700126I16Rik; AA960440; ARA3; FLARA3; HSPC068; IVNS1ABP; KIAA0850; KLHL39; mKIAA0850; ND1; Nd1-L; Nd1-S; Nd1L; Nd1S; NS-1; NS1; NS1-BP; NS1BP