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Proteintech
IWS1 Polyclonal Antibody
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Product Details
16943-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IWS1 Fusion Protein Ag10554 (523-819 aa encoded by BC017012)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
37.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: HMDFLSDFE MMLQRKKSMS GKRRRNRDGG TFISDADDVV SAMIVKMNEA AEEDRQLNNQ KKPALKKLTL LPAVVMHLKK QDLKETFIDS GVMSAIKEWL SPLPDRSLPA LKIREELLKI LQELPSVSQE TLKHSGIGRA VMYLYKHPKE SRSNKDMAGK LINEWSRPIF GLTSNYKGMT REEREQRDLE QMPQRRRMNS TGGQTPRRDL EKVLTGEEKA LRPGDPGFCA RARVPMPSNK DYVVRPKWNV EMESSRFQAT SKKGISRLDK QMRKFTDIRK KSRSAHAVKI SIEGNKMPL (523-819 aa encoded by BC017012)
Target Information
Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: interacts with Spt6; IWS1 homolog; IWS1, SUPT6H interacting protein; IWS1-like protein; Protein IWS1 homolog; unnamed protein product
Gene Aliases: 1700069O15Rik; 3000008H23; AL117927; AW214353; IWS1; IWS1L; RGD1304762
UniProt ID: (Human) Q96ST2, (Mouse) Q8C1D8, (Rat) Q3SWT4
Entrez Gene ID: (Human) 55677, (Mouse) 73473, (Rat) 291705
transcription, DNA-templated
regulation of transcription, DNA-templated
mRNA processing
transport
RNA splicing
regulation of mRNA export from nucleus
regulation of mRNA processing
mRNA transport
regulation of histone H4 acetylation
regulation of histone H3-K36 trimethylation
in utero embryonic development
chromatin remodeling
poly(A)+ mRNA export from nucleus
transcription elongation-coupled chromatin remodeling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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