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Proteintech
Icam-1 Polyclonal Antibody
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Product Details
16174-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.46 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specifically against mouse Icam-1.
Target Information
ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD54; Human rhinovirus receptor; ICAM-1; Intercellular adhesion molecule 1; Ly 47; MALA-2; MALA2; MyD10; sCD54; soluble CD54; Surface antigen of activated B cells
Gene Aliases: CD54; ICAM; Icam-1; Icam1; Ly-47; MALA-2
UniProt ID: (Mouse) P13597, (Rat) Q00238
Entrez Gene ID: (Mouse) 15894, (Rat) 25464
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
acute inflammatory response to antigenic stimulus
T cell antigen processing and presentation
positive regulation of cellular extravasation
cell adhesion
leukocyte cell-cell adhesion
sensory perception of sound
regulation of cell shape
single organismal cell-cell adhesion
regulation of cell adhesion
positive regulation of actin filament polymerization
cell adhesion mediated by integrin
positive regulation of GTPase activity
adhesion of symbiont to host
positive regulation of nitric oxide biosynthetic process
positive regulation of vasoconstriction
receptor-mediated virion attachment to host cell
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of NF-kappaB transcription factor activity
negative regulation of calcium ion transport
establishment of endothelial barrier
positive regulation of ERK1 and ERK2 cascade
cellular response to glucose stimulus
establishment of Sertoli cell barrier
regulation of ruffle assembly
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of endothelial cell apoptotic process
ovarian follicle development
response to hypoxia
response to amphetamine
cell aging
response to ionizing radiation
response to sulfur dioxide
response to organic cyclic compound
membrane to membrane docking
cellular response to nutrient levels
response to lipopolysaccharide
response to gonadotropin
response to drug
response to amino acid
response to ethanol
response to copper ion
leukocyte migration
cellular response to lipopolysaccharide
cellular response to organic substance
cellular response to alkaloid
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to hypoxia
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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