Immunogen sequence: AFLPYMESVF EEVFKLLECP HLNVRKAAHE ALGQFCCALH KACQSCPSEP NTAALQAALA RVVPSYMQAV NRERERQVVM AVLE
Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 77%.
Importin-4 is a protein that in humans is encoded by the IPO4 gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.
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Protein Aliases: Imp4; IMP4B; Importin-4; Importin-4b; Ran-binding protein 4; RANBP4
Gene Aliases: Imp4; IMP4B; IPO4; RANBP4
UniProt ID: (Human) Q8TEX9
Entrez Gene ID: (Human) 79711