Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
KLH conjugated synthetic peptide derived from mouse Inhibin Alpha, amino acids 301-366. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS with 1% BSA, 50% glycerol |
Contains |
0.09% sodium azide |
Storage conditions |
-20°C |
The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: A inhibin subunit; A-inhibin subunit; IHA; inhibin; Inhibin alpha chain
Gene Aliases: AW555078; INHA
UniProt ID: (Human) P05111, (Rat) P17490, (Mouse) Q04997
Entrez Gene ID: (Human) 3623, (Rat) 24504, (Mouse) 16322
Molecular Function:
growth factor
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