Bioss

Inhibin Alpha Polyclonal Antibody

View all (13) INHA antibodies

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Inhibin Alpha Antibody in Western Blot (WB) — Lane 1: rat brain lysates Lane 2: rat kidney lysates probed with Anti Inhibin Alpha Polyclonal Antibody, Unconjugated (bs-1032R) at 1:200 in 4°C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 90 min in 37°C. Predicted band 39 kD. Observed band size: 39 kD.

Inhibin Alpha Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Formalin-fixed and paraffin embedded rat ovary tissue labeled with Anti-Inhibin Alpha Polyclonal Antibody, Unconjugated (bs-1032R) at 1:200, followed by conjugation to the secondary antibody and DAB staining.

Product Details

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200

-

Immunofluorescence (IF)

1:100-1:500

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from mouse Inhibin Alpha.

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C

Target Information

The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A inhibin subunit; A-inhibin subunit; IHA; inhibin; Inhibin alpha chain

Gene Aliases: AW555078; INHA

UniProt ID: (Human) P05111, (Rat) P17490, (Mouse) Q04997

Entrez Gene ID: (Human) 3623, (Rat) 24504, (Mouse) 16322

Molecular Function: growth factor signaling molecule

skeletal system development ovarian follicle development cell cycle arrest signal transduction cell surface receptor signaling pathway cell-cell signaling nervous system development male gonad development response to external stimulus positive regulation of pathway-restricted SMAD protein phosphorylation cell differentiation erythrocyte differentiation regulation of cell proliferation negative regulation of phosphorylation hemoglobin biosynthetic process regulation of apoptotic process regulation of MAPK cascade negative regulation of interferon-gamma biosynthetic process negative regulation of B cell differentiation negative regulation of macrophage differentiation negative regulation of cell cycle positive regulation of follicle-stimulating hormone secretion negative regulation of follicle-stimulating hormone secretion cell development regulation of cell cycle SMAD protein signal transduction

Process(es)

receptor binding cytokine activity transforming growth factor beta receptor binding hormone activity protein binding growth factor activity inhibin binding protein heterodimerization activity