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Inhibin beta A Polyclonal Antibody

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Inhibin beta A Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of A549 cells using 10651-1-AP (Inhibin beta A antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Inhibin beta A Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lung cancer using 10651-1-AP (Inhibin beta A antibody) at dilution of 1:50 (under 40x lens).

Inhibin beta A Antibody in Western Blot (WB) — SGC-7901 cells were subjected to SDS PAGE followed by western blot with 10651-1-AP (Inhibin beta A antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Details

10651-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 1 publication 1 publication
Immunohistochemistry (IHC)	-	View 1 publication 1 publication
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunocytochemistry (ICC/IF)	1:20-1:200	-
Miscellaneous PubMed (Misc)	-	View 3 publications 3 publications

Product Specifications
Species Reactivity	Human
Published species	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Inhibin beta A Fusion Protein Ag1001 (126-426 aa encoded by BC007858) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.13 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: FAESGTARK TLHFEISKEG SDLSVVERAE VWLFLKVPKA NRTRTKVTIR LFQQQKHPQG SLDTGEEAEE VGLKGERSEL LLSEKVVDAR KSTWHVFPVS SSIQRLLDQG KSSLDVRIAC EQCQESGASL VLLGKKKKKE EEGEGKKKGG GEGGAGADEE KEQSHRPFLM LQARQSEDHP HRRRRRGLEC DGKVNICCKK QFFVSFKDIG WNDWIIAPSG YHANYCEGEC PSHIAGTSGS SLSFHSTVIN HYRMRGHSPF ANLKSCCVPT KLRPMSMLYY DDGQNIIKKD IQNMIVEECG CS (126-426 aa encoded by BC007858)

Target Information

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Activin A is a prominent autocrine regulator of hepatocyte growth arrest.

Hepatology communications

Haridoss S,Yovchev MI,Schweizer H,Megherhi S,Beecher M,Locker J,Oertel M

Wed Nov 01 00:00:00 EDT 2017

Esophageal squamous cell carcinoma invasion is inhibited by Activin A in ACVRIB-positive cells.

BMC cancer

Loomans HA,Arnold SA,Quast LL,Andl CD

Wed Nov 09 00:00:00 EST 2016

Combinatorial actions of Tgfβ and Activin ligands promote oligodendrocyte development and CNS myelination.

Development (Cambridge, England)

Dutta DJ,Zameer A,Mariani JN,Zhang J,Asp L,Huynh J,Mahase S,Laitman BM,Argaw AT,Mitiku N,Urbanski M,Melendez-Vasquez CV,Casaccia P,Hayot F,Bottinger EP,Brown CW,John GR

Sun Jun 01 00:00:00 EDT 2014

Evaluation of protein expression pattern of stanniocalcin 2, insulin-like growth factor-binding protein 7, inhibin beta A and four and a half LIM domains 1 in esophageal squamous cell carcinoma.

Cancer biomarkers : section A of Disease markers

Kashyap MK,Pawar HA,Keerthikumar S,Sharma J,Goel R,Mahmood R,Kumar MV,Kumar KV,Pandey A,Kumar RV,Prasad TS,Harsha HC

Fri Jul 12 00:00:00 EDT 2013

Action mechanism of inhibin α-subunit on the development of Sertoli cells and first wave of spermatogenesis in mice.

PloS one

Cai K,Hua G,Ahmad S,Liang A,Han L,Wu C,Yang F,Yang L

Mon Feb 13 00:00:00 EST 2012

Bioinformatics

Protein Aliases: Activin beta-A chain; EDF; erythroid differentiation factor; Erythroid differentiation protein; follicle-stimulating hormone-releasing protein; FSH-releasing protein; Inhibin beta A chain; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1

Gene Aliases: EDF; FRP; INHBA

UniProt ID: (Human) P08476

Entrez Gene ID: (Human) 3624

Molecular Function: growth factor

Function(s)

Process(es)

cytokine activity transforming growth factor beta receptor binding hormone activity protein binding growth factor activity peptide hormone binding inhibin binding identical protein binding protein heterodimerization activity type II activin receptor binding

Inhibin beta A Polyclonal Antibody

Product Details

10651-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Product Specific Information

Target Information

Bioinformatics

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