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Proteintech
Insulin Polyclonal Antibody
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FIGURE: 1 / 13
Insulin Antibody (15848-1-AP) in ICC/IF
Immunofluorescent analysis of (4% PFA) fixed human pancreas tissue using (Product # 15848-1-AP) (INS antibody) at dilution of 1:100 and CoraLite594-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). The α cells of the islets of Langerhans was labelled in green with 67286-1-Ig (Glucagon antibody).
Product Details
15848-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Insulin Fusion Protein Ag8630 (1-110 aa encoded by BC005255)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Amount
42 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MALWMRLLP LLALLALWGP DPAAAFVNQH LCGSHLVEAL YLVCGERGFF YTPKTRREAE DLQVGQVELG GGPGAGSLQP LALEGSLQKR GIVEQCCTSI CSLYQLENYC N (1-110 aa encoded by BC005255)
Target Information
Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Ins; INSU1; INSU2; INSU3B; INSUA; INSUB; INSUC; Insulin; insulin splice variant; insulin variant; INS-splice; Insulin-1; Insulin-2; preproinsulin; proinsulin
Gene Aliases: AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins-1; Ins-2; Ins1; Ins2; Ins2-rs1; InsII; IRDN; Mody; MODY10; Mody4; PNDM4; proinsulin
UniProt ID: (Human) P01308, (Rat) P01322, (Mouse) P01325, (Rat) P01323, (Mouse) P01326
Entrez Gene ID: (Human) 3630, (Rat) 24505, (Mouse) 16333, (Rat) 24506, (Mouse) 16334
positive regulation of cytokine production
negative regulation of acute inflammatory response
glucose metabolic process
regulation of transcription, DNA-templated
acute-phase response
G-protein coupled receptor signaling pathway
cell-cell signaling
positive regulation of cell proliferation
insulin receptor signaling pathway
positive regulation of gene expression
negative regulation of gene expression
positive regulation of nitric oxide mediated signal transduction
positive regulation of neuron projection development
positive regulation of cell growth
positive regulation of cell migration
regulation of protein localization
nitric oxide-cGMP-mediated signaling pathway
TORC1 signaling
wound healing
negative regulation of protein catabolic process
vasodilation
glucose homeostasis
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
positive regulation of cell differentiation
negative regulation of gluconeogenesis
positive regulation of glycogen biosynthetic process
positive regulation of translation
negative regulation of glycogen catabolic process
positive regulation of glycolytic process
positive regulation of mitotic nuclear division
negative regulation of fatty acid metabolic process
positive regulation of glucose import
positive regulation of insulin receptor signaling pathway
alpha-beta T cell activation
positive regulation of lipid biosynthetic process
regulation of synaptic plasticity
regulation of protein secretion
negative regulation of protein secretion
positive regulation of protein secretion
cognition
negative regulation of lipid catabolic process
positive regulation of nitric-oxide synthase activity
positive regulation of protein kinase B signaling
fatty acid homeostasis
negative regulation of respiratory burst involved in inflammatory response
positive regulation of respiratory burst
positive regulation of peptide hormone secretion
positive regulation of brown fat cell differentiation
positive regulation of protein localization to nucleus
positive regulation of long-term synaptic potentiation
cellular response to oxygen-containing compound
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of dendritic spine maintenance
regulation of protein localization to plasma membrane
negative regulation of reactive oxygen species biosynthetic process
neuron projection maintenance
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of feeding behavior
MAPK cascade
regulation of cellular amino acid metabolic process
response to organic substance
positive regulation of phosphatidylinositol 3-kinase signaling
glucose transport
regulation of transmembrane transporter activity
activation of protein kinase B activity
positive regulation of cellular protein metabolic process
negative regulation of protein oligomerization
negative regulation of NAD(P)H oxidase activity
response to cytokine
response to peptide hormone
positive regulation of DNA replication
negative regulation of proteolysis
positive regulation of cytokine secretion
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of NF-kappaB transcription factor activity
response to cAMP
carbohydrate metabolic process
negative regulation of transcription from RNA polymerase II promoter
activation of MAPK activity
ER overload response
myoblast fusion
biological_process
lipid catabolic process
regulation of protein binding
positive regulation of phosphatidylinositol 3-kinase activity
canonical Wnt signaling pathway
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
activation of JUN kinase activity
regulation of gene expression
myotube differentiation
regulation of phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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