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NeoBiotechnologies
Insulin Receptor Alpha Recombinant Rabbit Monoclonal Antibody (INSR, 2277R)
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Product Details
3643-RBM2-P1
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
INSR, 2277R
Immunogen
Recombinant fragment of extracellular domain of human Insulin Receptor alpha
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD220; CD220 beta; Insulin receptor; insulin receptor precursor; IR; IR alpha; IR beta; unnamed protein product
Gene Aliases: CD220; HHF5; INSR
UniProt ID: (Human) P06213
Entrez Gene ID: (Human) 3643
nucleotide binding
beta-amyloid binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
insulin-activated receptor activity
insulin-like growth factor receptor binding
structural molecule activity
protein binding
ATP binding
GTP binding
kinase activity
transferase activity
protein domain specific binding
protein kinase activator activity
insulin-like growth factor I binding
insulin-like growth factor II binding
cargo receptor activity
identical protein binding
phosphatidylinositol 3-kinase binding
insulin binding
insulin receptor substrate binding
macromolecular complex binding
PTB domain binding
positive regulation of receptor internalization
heart morphogenesis
regulation of glycogen biosynthetic process
regulation of transcription, DNA-templated
receptor-mediated endocytosis
transmembrane receptor protein tyrosine kinase signaling pathway
G-protein coupled receptor signaling pathway
learning
memory
positive regulation of cell proliferation
insulin receptor signaling pathway
epidermis development
male gonad development
organ morphogenesis
regulation of gene expression
positive regulation of macromolecule biosynthetic process
regulation of glucose metabolic process
male sex determination
adrenal gland development
positive regulation of cell migration
exocrine pancreas development
receptor internalization
cellular response to insulin stimulus
glucose homeostasis
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of protein complex disassembly
positive regulation of MAPK cascade
positive regulation of nitric oxide biosynthetic process
positive regulation of glycogen biosynthetic process
positive regulation of glycolytic process
positive regulation of mitotic nuclear division
positive regulation of transcription, DNA-templated
regulation of embryonic development
positive regulation of glucose import
viral entry into host cell
protein autophosphorylation
animal organ development
positive regulation of developmental growth
system development
positive regulation of cellular component organization
regulation of multicellular organismal process
positive regulation of meiotic cell cycle
positive regulation of protein kinase B signaling
positive regulation of respiratory burst
cellular response to growth factor stimulus
dendritic spine maintenance
beta-amyloid clearance
transport across blood-brain barrier
neuron projection maintenance
regulation of female gonad development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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