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Fabgennix

Insulin Receptor beta Polyclonal Antibody

View all (15) INSR beta antibodies

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Insulin Receptor beta Polyclonal Antibody

Product Details

INSRB-201AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 725-775 on human Insulin receptor beta subunit protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD220; CD220 beta; CD221; IGF-I receptor; Insulin receptor; insulin receptor precursor; insulin receptor preproprotein; IR; IR beta; unnamed protein product

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Gene Aliases: 4932439J01Rik; CD220; D630014A15Rik; HHF5; INSR; IR; IR-A; IR-B

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UniProt ID: (Human) P06213, (Mouse) P15208

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Entrez Gene ID: (Human) 3643, (Rat) 24954, (Mouse) 16337

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Function(s)
nucleotide binding beta-amyloid binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity insulin-activated receptor activity insulin-like growth factor receptor binding structural molecule activity protein binding ATP binding GTP binding kinase activity transferase activity protein domain specific binding protein kinase activator activity insulin-like growth factor I binding insulin-like growth factor II binding cargo receptor activity identical protein binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding macromolecular complex binding PTB domain binding receptor signaling protein tyrosine kinase activity protein kinase binding protein phosphatase binding lipoic acid binding protein complex binding 3-phosphoinositide-dependent protein kinase binding transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
Process(es)
positive regulation of receptor internalization heart morphogenesis regulation of glycogen biosynthetic process regulation of transcription, DNA-templated receptor-mediated endocytosis transmembrane receptor protein tyrosine kinase signaling pathway G-protein coupled receptor signaling pathway learning memory positive regulation of cell proliferation insulin receptor signaling pathway epidermis development male gonad development organ morphogenesis regulation of gene expression positive regulation of macromolecule biosynthetic process regulation of glucose metabolic process male sex determination adrenal gland development positive regulation of cell migration exocrine pancreas development receptor internalization cellular response to insulin stimulus glucose homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of protein complex disassembly positive regulation of MAPK cascade positive regulation of nitric oxide biosynthetic process positive regulation of glycogen biosynthetic process positive regulation of glycolytic process positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated regulation of embryonic development positive regulation of glucose import viral entry into host cell protein autophosphorylation animal organ development positive regulation of developmental growth system development positive regulation of cellular component organization regulation of multicellular organismal process positive regulation of meiotic cell cycle positive regulation of protein kinase B signaling positive regulation of respiratory burst cellular response to growth factor stimulus dendritic spine maintenance beta-amyloid clearance transport across blood-brain barrier neuron projection maintenance regulation of female gonad development activation of MAPK activity negative regulation of protein phosphorylation positive regulation of protein phosphorylation protein phosphorylation response to hormone response to glucose response to manganese ion regulation of hydrogen peroxide metabolic process positive regulation of glycoprotein biosynthetic process negative regulation of gene expression response to activity peptidyl-tyrosine phosphorylation transformation of host cell by virus signal transduction by protein phosphorylation response to nutrient levels activation of protein kinase activity activation of protein kinase B activity response to estradiol negative regulation of transporter activity response to insulin response to vitamin D response to testosterone response to tumor necrosis factor peptidyl-tyrosine autophosphorylation positive regulation of phosphorylation fat cell differentiation response to ethanol positive regulation of DNA replication protein heterotetramerization response to glucocorticoid phosphorylation intracellular signal transduction
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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