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Bioss

Integrin Alpha V + Beta 5 Polyclonal Antibody

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Product Details

BS-1356R

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Integrin beta 5 and Integrin alpha V.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha v integrin; antigen identified by monoclonal antibody L230; CD51; Dnmt3l-ps1 pseudogene; Integrin alpha-V; integrin alphaVbeta3; Integrin beta-5; integrin beta-5 subunit; integrin beta-5 subunit precursor; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); testis secretory sperm-binding protein Li 217p; unnamed protein product; vitronectin alpha subunit precursor; Vitronectin receptor; vitronectin receptor alpha polypeptide (VNRA); Vitronectin receptor subunit alpha

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Gene Aliases: 1110004F14Rik; 2610028E01Rik; [b]-5; [b]5; [b]5A; [b]5B; AA475909; AI874634; beta-5; beta5; CD51; D430040G12Rik; ESTM23; ITGAV; ITGB5; MSK8; RGD1563276; VNRA; VTNR

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UniProt ID: (Human) P06756, (Human) P18084, (Mouse) P43406, (Mouse) O70309

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Entrez Gene ID: (Human) 3685, (Human) 3693, (Rat) 296456, (Mouse) 16410, (Rat) 257645, (Mouse) 16419

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Function(s)
virus receptor activity opsonin binding fibronectin binding protease binding protein kinase C binding receptor binding integrin binding protein binding coreceptor activity fibroblast growth factor binding C-X3-C chemokine binding insulin-like growth factor I binding signaling receptor activity neuregulin binding metal ion binding transforming growth factor beta binding extracellular matrix binding extracellular matrix protein binding voltage-gated calcium channel activity peptide binding protein heterodimerization activity receptor activity integrin
Process(es)
angiogenesis blood vessel development vasculogenesis formation of primary germ layer cell adhesion cell-matrix adhesion positive regulation of cytosolic calcium ion concentration integrin-mediated signaling pathway positive regulation of cell proliferation tissue development negative regulation of macrophage derived foam cell differentiation negative regulation of lipid storage negative regulation of low-density lipoprotein particle clearance cell migration positive regulation of cell migration cell-substrate adhesion negative regulation of lipid transport cell adhesion mediated by integrin positive regulation of osteoblast proliferation heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading wound healing, spreading of epidermal cells endodermal cell differentiation apolipoprotein A-I-mediated signaling pathway apoptotic cell clearance positive regulation of cell adhesion viral entry into host cell negative regulation of lipoprotein metabolic process regulation of phagocytosis negative chemotaxis positive regulation of small GTPase mediated signal transduction ERK1 and ERK2 cascade calcium ion transmembrane transport transforming growth factor beta production entry into host cell by a symbiont-containing vacuole extrinsic apoptotic signaling pathway in absence of ligand cell-cell adhesion positive regulation of intracellular signal transduction negative regulation of entry of bacterium into host cell negative regulation of extrinsic apoptotic signaling pathway transforming growth factor beta receptor signaling pathway stress fiber assembly epithelial cell-cell adhesion cellular calcium ion homeostasis cell growth positive regulation of MAPK cascade negative regulation of low-density lipoprotein particle receptor biosynthetic process regulation of apoptotic cell clearance inflammatory response multicellular organism development fertilization cell differentiation detection of molecule of bacterial origin regulation of ion transmembrane transport gonad morphogenesis T cell activation endothelial cell migration regulation of bone resorption focal adhesion assembly release of sequestered calcium ion into cytosol trophoblast giant cell differentiation response to nitric oxide biological_process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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