Bioss

Integrin alpha 2/CD49b Polyclonal Antibody

View all (57) CD49b (Integrin alpha 2) antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Integrin alpha 2/CD49b Polyclonal Antibody

Product Details

BS-10132R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Integrin alpha 2/CD49b, amino acids 801-900.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: alpha 2 subunit of VLA-2 receptor; BDPLT9; CD49 antigen-like family member B; CD49b; Collagen receptor; GPIa; human platelet alloantigen system 5; Integrin alpha-2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); platelet antigen Br; platelet glycoprotein GPIa; Platelet membrane glycoprotein Ia; very late activation protein 2 receptor, alpha-2 subunit; VLA-2 receptor, alpha 2 subunit; VLA-2 subunit alpha; VLA2 receptor

View more View less

Gene Aliases: BR; CD49B; DX5; GPIa; HPA-5; ITGA2; VLA-2; VLAA2

View more View less

UniProt ID: (Human) P17301, (Mouse) Q62469

View more View less

Entrez Gene ID: (Human) 3673, (Mouse) 16398, (Rat) 170921

View more View less

Function(s)
virus receptor activity integrin binding protein binding collagen binding protein complex binding collagen receptor activity laminin binding metal ion binding protein heterodimerization activity collagen binding involved in cell-matrix adhesion cell adhesion molecule binding integrin
Process(es)
response to hypoxia positive regulation of leukocyte migration substrate-dependent cell migration hypotonic response cell adhesion cell-matrix adhesion integrin-mediated signaling pathway female pregnancy blood coagulation cell proliferation organ morphogenesis positive regulation of epithelial cell migration positive regulation of alkaline phosphatase activity response to amine response to muscle activity positive regulation of smooth muscle cell migration extracellular matrix organization mammary gland development positive regulation of cell projection organization cell-substrate adhesion positive regulation of collagen biosynthetic process positive regulation of collagen binding response to L-ascorbic acid cell adhesion mediated by integrin collagen-activated signaling pathway response to drug positive regulation of DNA binding skin morphogenesis establishment of protein localization positive regulation of translation positive regulation of cell adhesion positive regulation of smooth muscle contraction viral entry into host cell focal adhesion assembly mesodermal cell differentiation positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response positive regulation of positive chemotaxis detection of mechanical stimulus involved in sensory perception of pain positive regulation of transmission of nerve impulse positive regulation of phagocytosis, engulfment hepatocyte differentiation response to parathyroid hormone cellular response to mechanical stimulus cellular response to estradiol stimulus movement of cell or subcellular component response to organic cyclic compound wound healing cellular response to organic cyclic compound
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support