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Proteintech
Integrin alpha-6 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
27189-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Hamster
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Integrin alpha-6 Fusion Protein Ag25835 (477-690 aa encoded by BC136456)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TPNRIDLRQ KTACGAPSGI CLQVKSCFEY TANPAGYNPS ISIVGTLEAE KERRKSGLSS RVQFRNQGSE PKYTQELTLK RQKQKVCMEE TLWLQDNIRD KLRPIPITAS VEIQEPSSRR RVNSLPEVLP ILNSDEPKTA HIDVHFLKEG CGDDNVCNSN LKLEYKFCTR EGNQDKFSYL PIQKGVPELV LKDQKDIALE ITVTNSPSNP RNPTK (477-690 aa encoded by BC136456)
Target Information
CDf (Integrin alpha-6, ITGA6) is the integrin alpha chain alpha 6 protein. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signaling. Two transcript variants encoding different isoforms have been found for CDf. Functionally, integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals that affect cellular shape, mobility, and progression through the cell cycle in response to the extracellular matrix. Integrin receptors are composed of alpha and beta subunits, and form structural and functional linkages between the ECM (extra-cellular matrix) and intracellular cytoskeletal linker proteins. Signaling mediated by Intergrin/ECM interactions are also integrated with cellular responses to growth factor signaling to regulate cellular proliferation, cytoskeletal reorganization and other responses necessary for cellular survival. CDf is predominantly expressed by epithelia, and plays a critical structural role in the hemidesmosome. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD49 antigen-like family member F; DKFZp686J01244; extracellular matrix receptor subunit; FLJ18737; integrin alpha6B; integrin, alpha 6; unnamed protein product; very late activation protein 6
Gene Aliases: 5033401O05Rik; CD49f; ITGA6A; ITGA6B; JEB6; VLA-6
UniProt ID: (Human) P23229, (Mouse) Q61739
Entrez Gene ID: (Human) 3655, (Mouse) 16403, (Rat) 114517
cell-substrate junction assembly
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
ectodermal cell differentiation
positive regulation of neuron projection development
positive regulation of cell migration
cell-substrate adhesion
nail development
positive regulation of apoptotic process
positive regulation of GTPase activity
skin morphogenesis
positive regulation of transcription from RNA polymerase II promoter
leukocyte migration
cell-cell adhesion
negative regulation of extrinsic apoptotic signaling pathway
positive regulation of cell-substrate adhesion
positive regulation of cell-cell adhesion
cell adhesion mediated by integrin
odontogenesis of dentin-containing tooth
filopodium assembly
brown fat cell differentiation
cellular response to phorbol 13-acetate 12-myristate
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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