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Integrin linked ILK Polyclonal Antibody

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Integrin linked ILK Polyclonal Antibody

Product Details

ILK-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 400-452 on human Integrin-linked protein kinase.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 59 kDa serine/threonine-protein kinase; beta-integrin-linked kinase; epididymis secretory protein Li 28; ILK; ILK-1; ILK-2; Inactive integrin-linked kinase; integrin binding protein kinase; Integrin linked ILK; integrin linked kinase; integrin-linked kinase-2; integrin-linked protein kinase; p59ILK; Scaffold protein ILK; unnamed protein product

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Gene Aliases: AA511515; ESTM24; HEL-S-28; ILK; ILK-1; ILK-2; ILK1; ILK2; P59; p59ILK

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UniProt ID: (Human) Q13418, (Mouse) O55222, (Rat) Q99J82

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Entrez Gene ID: (Human) 3611, (Mouse) 16202, (Rat) 170922

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Function(s)
nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity receptor binding integrin binding protein binding ATP binding protein kinase binding protein binding, bridging metal ion binding signal transducer activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups SH3 domain binding protein domain specific binding non-receptor serine/threonine protein kinase
Process(es)
cell morphogenesis branching involved in ureteric bud morphogenesis outflow tract morphogenesis mitotic spindle organization cell-matrix adhesion integrin-mediated signaling pathway cell proliferation positive regulation of cell proliferation anatomical structure morphogenesis positive regulation of signal transduction fibroblast migration Schwann cell development nerve development myelination in peripheral nervous system cell projection organization cell differentiation positive regulation of BMP signaling pathway tumor necrosis factor-mediated signaling pathway substrate adhesion-dependent cell spreading positive regulation of I-kappaB kinase/NF-kappaB signaling protein kinase B signaling establishment or maintenance of epithelial cell apical/basal polarity positive regulation of osteoblast differentiation positive regulation of transcription, DNA-templated neural precursor cell proliferation platelet aggregation caveola assembly protein localization to cell cortex positive regulation of canonical Wnt signaling pathway positive regulation of substrate adhesion-dependent cell spreading negative regulation of neural precursor cell proliferation regulation of cell growth positive regulation of cell-matrix adhesion protein phosphorylation negative regulation of protein kinase activity cell cycle arrest cell aging regulation of signal transduction negative regulation of cardiac muscle cell apoptotic process negative regulation of smooth muscle cell migration phosphorylation peptidyl-serine phosphorylation positive regulation of cell migration myelin assembly regulation of actin cytoskeleton organization positive regulation of phosphorylation negative regulation of apoptotic process extracellular fibril organization positive regulation of MAP kinase activity positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of myoblast differentiation positive regulation of axon extension negative regulation of smooth muscle cell proliferation neuron projection morphogenesis positive regulation of axonogenesis positive regulation of dendrite morphogenesis protein heterooligomerization positive regulation of protein kinase B signaling
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