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Bethyl Laboratories
Intersectin 1 Polyclonal Antibody
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FIGURE: 1 / 2
Intersectin 1 Antibody (A303-075A) in WB
Detection of human and mouse Intersectin-1 by western blot. Samples: Whole cell lysate (15 µg) from HeLa, HEK293T, Jurkat, TCMK-1, and NIH 3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified Rabbit anti-Intersectin-1 antibody (Product # A303-075A) (lot A303-075A-2) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A303-075A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 850 and 900 of human Intersectin 1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EH and SH3 domains protein 1; Eh domain, SH3 domain regulator of endocytosis 1; human intersectin-SH3 domain-containing protein SH3P17; intersectin (SH3 domain protein 1A); intersectin 1 (SH3 domain protein); intersectin short form 2 variant 2; Intersectin-1; intersectin-L; MGC134948; MGC134949; SH3 domain-containing protein 1A; SH3P17; Src homology 3 domain-containing protein; subject to NMD; unnamed protein product
Gene Aliases: AA517634; AA545208; AI316805; AI839402; AI848451; Ehsh1; Ese1; ITSN; ITSN1; SH3D1A; SH3P17
UniProt ID: (Human) Q15811, (Mouse) Q9Z0R4
Entrez Gene ID: (Human) 6453, (Mouse) 16443
guanyl-nucleotide exchange factor activity
calcium ion binding
protein binding
protein binding, bridging
metal ion binding
binding, bridging
proline-rich region binding
Rho guanyl-nucleotide exchange factor activity
kinase activator activity
protein complex scaffold
guanyl-nucleotide exchange factor
membrane traffic protein
exocytosis
endocytosis
protein localization
regulation of cell communication
protein transport
endosomal transport
regulation of signaling
intracellular signal transduction
regulation of small GTPase mediated signal transduction
positive regulation of growth hormone secretion
positive regulation of dendritic spine development
regulation of postsynapse organization
clathrin-dependent synaptic vesicle endocytosis
regulation of modification of postsynaptic actin cytoskeleton
positive regulation of caveolin-mediated endocytosis
small GTPase mediated signal transduction
regulation of Rho protein signal transduction
positive regulation of phosphorylation
positive regulation of catalytic activity
negative regulation of neuron apoptotic process
positive regulation of protein kinase B signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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