Immunogen sequence: QQHTLPVTLS PALSQELLKT VPPPVNTHQE QMKQPTPLPP PCQKVPVELP VEVPSKQEEK HMTAVKGLPE QECEQ
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions and is reduced in severe dysplasias of the larynx and cervix. Its gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.
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Protein Aliases: Involucrin
Gene Aliases: IVL
UniProt ID: (Human) P07476
Entrez Gene ID: (Human) 3713