This target displays homology in the following species: Cow: 93%; Dog: 92%; Guinea Pig: 86%; Horse: 100%; Human: 93%; Mouse: 100%; Pig: 93%; Rabbit: 86%; Rat: 100%
Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina. Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.
Protein Aliases: Homeodomain protein IRXB2; Iroquois homeobox protein 5; Iroquois-class homeodomain protein IRX-5
Gene Aliases: Irx5; Irxb2
UniProt ID: (Mouse) Q9JKQ4
Entrez Gene ID: (Mouse) 54352
Molecular Function: homeodomain transcription factor