Search
AbboMax
JAK1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
600-350
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide derived from the adjacent to C-terminus of JAK1 protein
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with proprietary stabilizer
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: Skeletal muscle
Cellular location: Cytoplasm.
Target Information
Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: EC 2.7.10.2; JAK-1; Janus kinase 1; Janus protein tyrosine kinase 1; kinase Jak1; Tyrosine-protein kinase JAK1
Gene Aliases: AA960307; AIIDE; BAP004; C130039L05Rik; JAK1; JAK1A; JAK1B; JTK3
UniProt ID: (Human) P23458
Entrez Gene ID: (Human) 3716, (Rat) 84598, (Mouse) 16451
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
growth hormone receptor binding
protein binding
ATP binding
kinase activity
transferase activity
protein phosphatase binding
ubiquitin protein ligase binding
CCR5 chemokine receptor binding
metal ion binding
transferase activity, transferring phosphorus-containing groups
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
cell migration
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
cell differentiation
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
interleukin-2-mediated signaling pathway
regulation of cell proliferation
innate immune response
response to antibiotic
protein autophosphorylation
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
JAK-STAT cascade
regulation of cell-cell adhesion
positive regulation of homotypic cell-cell adhesion
interleukin-15-mediated signaling pathway
interleukin-4-mediated signaling pathway
interleukin-7-mediated signaling pathway
interleukin-9-mediated signaling pathway
interleukin-11-mediated signaling pathway
type III interferon-mediated signaling pathway
regulation of multicellular organismal process
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
interleukin-6-mediated signaling pathway
T-helper 17 cell lineage commitment
cellular response to virus
cellular response to interleukin-7
interleukin-10-mediated signaling pathway
protein localization to cell-cell junction
positive regulation of protein localization to nucleus
positive regulation of sprouting angiogenesis
phosphorylation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support