The protein encoded by this gene is a member of the Janus kinase family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: JAK-3; JAK3; Janus kinase 3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); Janus kinase 3 protein-tyrosine kinase; Janus kinase 3, protein-tyrosine kinase; L-JAK; Leukocyte janus kinase; Tyrosine-protein kinase JAK3
Gene Aliases: fae; JAK-3; JAK3; JAK3_HUMAN; JAKL; L-JAK; LJAK; RATJAK3; wil