Immunogen sequence: TELALLIQQC MAYEPVQRPS FRAVIRDLNS LISSDYELLS DPTPGALAPR DGLWNGAQLY ACQDPTIFEE RHLKYISQLG KGNFGSVELC RYDPLGDNTG A; Positive Samples: U-87MG; Cellular Location: Cytoplasm, Endomembrane system, Peripheral membrane protein
JAK3 encodes Janus kinase 3, a tyrosine kinase that belongs to the Janus family. JAK3 functions in signal transduction and interacts with members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations that abrogate Janus kinase 3 function cause an autosomal SCID (severe combined immunodeficiency disease).
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Protein Aliases: JAK-3; Janus kinase 3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); L-JAK; Leukocyte janus kinase; Tyrosine-protein kinase JAK3
Gene Aliases: JAK-3; JAK3; JAK3_HUMAN; JAKL; L-JAK; LJAK
UniProt ID: (Human) P52333
Entrez Gene ID: (Human) 3718