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Invitrogen

JAK3 Polyclonal Antibody

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JAK3 Polyclonal Antibody

Product Details

PA5-87500

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 350-530 of JAK3 (NP_0002062)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.13 mg/mL

Amount

213 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2804203

Product Specific Information

Immunogen sequence: RLTTDSQHFF CKEVAPPRLL EEVAEQCHGP ITLDFAINKL KTGGSRPGSY VLRRSPQDFD SFLLTVCVQN PLGPDYKGCL IRRSPTGTFL LVGLSRPHSS LRELLATCWD GGLHVDGVAV TLTSCCIPRP KEKSNLIVVQ RGHSPPTSSL VQPQSQYQLS QMTFHKIPAD SLEWHENLGH G

Positive Samples: U-87MG; Cellular Location: Cytoplasm, Endomembrane system, Peripheral membrane protein

Target Information

Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to activation of interleukin receptors. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. However, active JAK1 may be required for complex responses. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Breast-JAK3; JAK-3; JAK3B; Janus kinase 3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); L JAK; L-JAK; Leukocyte janus kinase; Tyrosine-protein kinase JAK3; unnamed protein product

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Gene Aliases: JAK-3; JAK3; JAK3_HUMAN; JAKL; L-JAK; LJAK

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UniProt ID: (Human) P52333

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Entrez Gene ID: (Human) 3718

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity growth hormone receptor binding protein binding ATP binding kinase activity transferase activity protein phosphatase binding
Process(es)
adaptive immune response immune system process negative regulation of dendritic cell cytokine production enzyme linked receptor protein signaling pathway JAK-STAT cascade tyrosine phosphorylation of STAT protein negative regulation of glycoprotein biosynthetic process cytokine-mediated signaling pathway cell differentiation B cell differentiation negative regulation of interleukin-10 production negative regulation of interleukin-12 production intracellular signal transduction interleukin-15-mediated signaling pathway interleukin-4-mediated signaling pathway interleukin-2-mediated signaling pathway interleukin-7-mediated signaling pathway interleukin-9-mediated signaling pathway regulation of apoptotic process T cell homeostasis innate immune response negative regulation of T-helper 1 cell differentiation regulation of JAK-STAT cascade regulation of alpha-beta T cell activation negative regulation of T cell activation JAK-STAT cascade involved in growth hormone signaling pathway regulation of T cell apoptotic process negative regulation of thymocyte apoptotic process response to interleukin-2 response to interleukin-4 response to interleukin-15 response to interleukin-9 regulation of leukocyte cell-cell adhesion negative regulation of T-helper 17 cell lineage commitment
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