FIGURE: 1 / 2
Immunogen sequence: LVEKNKRMNK KNEDLLQSIQ RMEEKIKNLT RENVEMKEKL SAQASLKRHT SLNDLSLTRD EQEIEFLRLQ VLEQQHVIDD LSL
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 96%.
JAKMIP1, also known as Marlin-1, is a highly-conserved vertebrate-specific microtubule-associated protein that plays a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements. JAKMIP1 is expressed predominantly in neuronal and lymphoid cells and colocalizes with microtubules. Multiple isoforms of JAKMIP1 are known to exist: isoforms 1 and 5 are also expressed in liver, lung and skeletal muscle, while isoforms 2-4 are specifically expressed in brain and retina. JAKMIP1 participates in polarized secretion in lymphocytes and it has been suggested to be a novel effector memory gene restraining T cell-mediated cytotoxicity. Dysregulation of JAKMIP1 gene expression is associated with genetic conditions linked to autism in humans.
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Protein Aliases: FLJ31564; GABA-B receptor-binding protein; Jak and microtubule interacting protein 1; Janus kinase and microtubule-interacting protein 1; Marlin-1; Multiple alpha-helices and RNA-linker protein 1; multiple coiled-coil GABABR1-binding protein
Gene Aliases: GABABRBP; JAKMIP1; JAMIP1; MARLIN1
UniProt ID: (Human) Q96N16
Entrez Gene ID: (Human) 152789