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FIGURE: 1 / 2
Purity is > 95% by SDS-PAGE.
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AU016127; CD322; JAM-2; JAM-B; JAM-IT/VE-JAM; junction adhesion molecule 2; junction adhesion molecule B; junction cell adhesion molecule 2; Junctional adhesion molecule 2; Junctional adhesion molecule B; RP23-253E17.2; Vascular endothelial junction-associated molecule; VE-JAM
Gene Aliases: 1110002N23Rik; 2410030G21Rik; 2410167M24Rik; C21orf43; CD322; JAM-2; JAM-B; JAM2; JAMB; Jcam2; PRO245; UNQ219/PRO245; VE-JAM; VEJAM
UniProt ID: (Human) P57087, (Mouse) Q9JI59
Entrez Gene ID: (Human) 58494, (Mouse) 67374, (Rat) 619374
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