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Invitrogen
JIP2 Polyclonal Antibody
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FIGURE: 1 / 5
JIP2 Antibody (PA5-101157) in ICC/IF
Immunocytochemistry analysis of JIP2 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with JIP2 polyclonal antibody (Product # PA5-101157) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-101157
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MAPK8IP2(Accession Q13387), corresponding to amino acid residues V581-V631.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total JIP2.
Target Information
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-Jun-amino-terminal kinase-interacting protein 2; homologous to mouse JIP-1; IB 2; IB-2; IB2; Islet brain 2; islet-brain 2; Islet-brain-2; JIP 2; JIP-2; JNK interacting protein 2; JNK MAP kinase scaffold protein 2; JNK MAP kinase scaffold protein JIP2; JNK-interacting protein 2; mitogen activated protein kinase 8 interacting protein 2; Mitogen-activated protein kinase 8-interacting protein 2; unnamed protein product
Gene Aliases: 3230402N03Rik; AI847694; AW049958; IB-2; IB2; JIP2; MAPK8IP2; PRKM8IPL; R75148; si:dkey-180h12.2; si:dkey-181m21.1
UniProt ID: (Human) Q13387, (Mouse) Q9ERE9, (Rat) G3V9M2
Entrez Gene ID: (Human) 23542, (Mouse) 60597, (Rat) 315220, (Zebrafish) 561262
beta-amyloid binding
MAP-kinase scaffold activity
structural molecule activity
protein binding
JUN kinase binding
kinesin binding
protein kinase binding
protein kinase activator activity
macromolecular complex binding
protein complex binding
kinase activity
transferase activity
scaffold/adaptor protein
MAPK cascade
behavioral fear response
signal complex assembly
JNK cascade
mating behavior
positive regulation of stress-activated MAPK cascade
social behavior
regulation of JNK cascade
nonassociative learning
dendrite morphogenesis
regulation of synaptic transmission, glutamatergic
modulation of excitatory postsynaptic potential
negative regulation of apoptotic signaling pathway
regulation of receptor activity
positive regulation of protein kinase activity
excitatory postsynaptic potential
regulation of N-methyl-D-aspartate selective glutamate receptor activity
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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