PA5-29245 targets JIP2 in IF and WB applications and shows reactivity with Human and mouse samples.
The PA5-29245 immunogen is recombinant fragment corresponding to a region within amino acids 529 and 804 of Human JIP2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
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Protein Aliases: C-Jun-amino-terminal kinase-interacting protein 2; homologous to mouse JIP-1; IB-2; IB2; islet-brain 2; Islet-brain-2; JIP-2; JIP2; JNK MAP kinase scaffold protein 2; JNK MAP kinase scaffold protein JIP2; JNK-interacting protein 2; mitogen activated protein kinase 8 interacting protein 2; mitogen-activated protein kinase 8-interact; Mitogen-activated protein kinase 8-interacting protein 2; PRKM8IPL
Gene Aliases: 3230402N03Rik; AI847694; AW049958; IB-2; IB2; JIP2; MAPK8IP2; PRKM8IPL; R75148