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Invitrogen
JIP3 Polyclonal Antibody
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FIGURE: 1 / 2
JIP3 Antibody (PA5-101272) in IHC (P)
Immunohistochemistry analysis of JIP3 in rat heart tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with JIP3 polyclonal antibody (Product # PA5-101272) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-101272
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MAPK8IP3(Accession Q9UPT6), corresponding to amino acid residues V713-L763.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total JIP3.
Target Information
c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites Ser 63 and Ser 73, resulting in transcriptional activation. Two additional JNK family members, JNK2 and JNK3, have been identified. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1; C-jun-amino-terminal kinase interacting protein 3; C-Jun-amino-terminal kinase-interacting protein 3; homolog of Drosophila Sunday driver 2; JIP-3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JNK/SAPK-associated protein 1; JNK/SAPK-associated protein 1c; JNK/SAPK-associated protein-1; JNK/stress-activated protein kinase-associated protein 1; JSAP1; JUN/SAPK-associated protein 1; mitogen activated protein kinase 8 interacting protein 3; Mitogen-activated protein kinase 8-interacting protein 3; stress-activated protein kinase-associated protein 1; Sunday driver 2
Gene Aliases: BB120594; D17Wsu15e; JIP-3; JIP3; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; KIAA1066; MAPK8IP3; mKIAA1066; NEDBA; syd; SYD2
UniProt ID: (Human) Q9UPT6, (Mouse) Q9ESN9
Entrez Gene ID: (Human) 23162, (Mouse) 30957
MAPK cascade
vesicle-mediated transport
axon regeneration
negative regulation of apoptotic process
regulation of JNK cascade
positive regulation of JNK cascade
protein stabilization
axon development
anterograde axonal protein transport
in utero embryonic development
JNK cascade
activation of JUN kinase activity
axon guidance
respiratory gaseous exchange
protein localization
post-embryonic development
positive regulation of signal transduction
regulation of gene expression
forebrain development
positive regulation of JUN kinase activity
positive regulation of neuron differentiation
lung alveolus development
lung morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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