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Invitrogen
JMJD1A Polyclonal Antibody
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Product Details
PA5-20802
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 16 amino acid peptide from near the amino terminus of human JMJD1A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is mouse liver tissue lysate.
PA5-20802 can be used with blocking peptide PEP-0916.
Target Information
JMJD1A is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. It preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. JMJD1A is involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. It's also Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [histone H3]-dimethyl-L-lysine(9) demethylase 3A; DKFZp686A24246; DKFZp686P07111; JmjC domain-containing histone demethylation protein 2A; jumonji C domain-containing histone demethylase 2A; jumonji domain containing 1A; Jumonji domain-containing protein 1A; lysine (K)-specific demethylase 3A; Lysine-specific demethylase 3A; probable zinc finger protein; Testis-specific gene A protein; testis-specific protein A; unnamed protein product; Zinc finger protein TSGA
Gene Aliases: JHDM2A; JHMD2A; JMJD1; JMJD1A; KDM3A; KIAA0742; TSGA
UniProt ID: (Human) Q9Y4C1, (Rat) Q63679
Entrez Gene ID: (Human) 55818, (Rat) 312440
chromatin binding
transcription cofactor activity
iron ion binding
protein binding
zinc ion binding
oxidoreductase activity
chromatin DNA binding
histone demethylase activity (H3-K9 specific)
metal ion binding
androgen receptor binding
dioxygenase activity
histone H3K9me/H3K9me2 demethylase activity
transcription regulatory region sequence-specific DNA binding
core promoter binding
molecular_function
transcription factor activity, sequence-specific DNA binding
histone modifying enzyme
chromatin organization
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
spermatogenesis
spermatid nucleus elongation
hormone-mediated signaling pathway
regulation of gene expression
cell differentiation
androgen receptor signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
formaldehyde biosynthetic process
positive regulation of cold-induced thermogenesis
cellular response to leukemia inhibitory factor
regulation of stem cell population maintenance
regulation of stem cell differentiation
response to hypoxia
transcription, DNA-templated
regulation of transcription, DNA-templated
male gonad development
positive regulation of gene expression
chromatin modification
histone H3-K9 demethylation
histone H3-K9 dimethylation
negative regulation of histone H3-K9 methylation
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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