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Invitrogen
JMJD1B Polyclonal Antibody
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FIGURE: 1 / 9
JMJD1B Antibody (PA5-17170) in ICC/IF
Knockdown of JMJD1B was achieved by transfecting IMR-32 cells with JMJD1B specific siRNA (Silencer® select Product # s28657, s224243). Immunofluorescence analysis was performed on untransfected IMR-32 cells (panel a,d), transfected with non-specific scrambled siRNA (panels e, h) and transfected with JMJD1B specific siRNA (panel i, l). Cells were fixed, permeabilized, and labelled with JMJD1B Polyclonal Antibody (Product # PA5-17170, 1:100 dilution) followed by Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Flu... View More
Product Details
PA5-17170
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the human JMJD1B protein
Conjugate
Form
Liquid
Concentration
9.1 µg/mL
Amount
0.91 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: [histone H3]-dimethyl-L-lysine(9) demethylase 3B; JmjC domain-containing histone demethylation protein 2B; jumonji domain containing 1B; Jumonji domain-containing protein 1B; lysine (K)-specific demethylase 3B; Lysine-specific demethylase 3B; Nuclear protein 5qNCA; PZP; unnamed protein product
Gene Aliases: 5830462I21Rik; 5qNCA; C5orf7; DIJOS; JHDM2B; JMJD1B; KDM3B; KIAA1082; mKIAA1082; NET22
UniProt ID: (Human) Q7LBC6, (Mouse) Q6ZPY7
Entrez Gene ID: (Human) 51780, (Mouse) 277250, (Rat) 682469
transcription cofactor activity
zinc ion binding
oxidoreductase activity
chromatin DNA binding
histone demethylase activity (H3-K9 specific)
metal ion binding
dioxygenase activity
histone H3K9me/H3K9me2 demethylase activity
sulfonate dioxygenase activity
molecular_function
antioxidant activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
histone modifying enzyme
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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