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Invitrogen
JMJD2A Polyclonal Antibody
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Product Details
PA5-20806
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 14 amino acid peptide from near the center of human JMJD2A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is rat liver tissue lysate.
PA5-20806 can be used with blocking peptide PEP-0920.
Target Information
JMJD2A is a member of the Jumonji domain 2 (JMJD2) family and a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A; JmjC domain-containing histone demethylation protein 3A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2; jumonji domain containing 2A; Jumonji domain-containing protein 2A; lysine (K)-specific demethylase 4A; Lysine-specific demethylase 4A; tudor domain containing 14A; unnamed protein product
Gene Aliases: D4Ertd222e; JHDM3A; JMJD2; JMJD2A; KDM4A; KIAA0677; mKIAA0677; TDRD14A
UniProt ID: (Human) O75164, (Mouse) Q8BW72
Entrez Gene ID: (Human) 9682, (Rat) 313539, (Mouse) 230674
protein binding
zinc ion binding
oxidoreductase activity
ubiquitin protein ligase binding
histone demethylase activity
histone demethylase activity (H3-K9 specific)
metal ion binding
dioxygenase activity
histone demethylase activity (H3-K36 specific)
histone H4K20me2 reader activity
histone H3K36me2/H3K36me3 demethylase activity
histone H3K9me2/H3K9me3 demethylase activity
double-stranded DNA binding
methylated histone binding
sulfonate dioxygenase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
histone modifying enzyme
chromatin organization
chromatin remodeling
regulation of gene expression
negative regulation of autophagy
negative regulation of gene expression
cardiac muscle hypertrophy in response to stress
negative regulation of transcription, DNA-templated
positive regulation of gene expression
histone demethylation
response to nutrient levels
positive regulation of neuron differentiation
negative regulation of astrocyte differentiation
negative regulation of cell death
histone H3-K36 demethylation
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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