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Invitrogen
| Applications | Tested Dilution | Publications |
|---|---|---|
Immunohistochemistry (IHC) |
1:50-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 825-1064 of human KDM4A |
Conjugate |
Unconjugated |
Form |
liquid |
Concentration |
6.85 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2805036 |
Immunogen sequence: RFKLKCIFCK KRRKRTAGCC VQCSHGRCPT AFHVSCAQAA GVMMQPDDWP FVVFITCFRH KIPNLERAKG ALQSITAGQK VISKHKNGRF YQCEVVRLTT ETFYEVNFDD GSFSDNLYPE DIVSQDCLQF GPPAEGEVVQ VRWTDGQVYG AKFVASHPIQ MYQVEFEDGS QLVVKRDDVY TLDEELPKRV KSRLSVASDM RFNEIFTEKE VKQEKKRQRV INSRYREDYI EPALYRAIME; Positive Samples: NIH/3T3, Mouse spleen, Mouse brain, Mouse lung; Cellular Location: Nucleus
JMJD2A is a member of the Jumonji domain 2 (JMJD2) family and a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A; JmjC domain-containing histone demethylation protein 3A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2; jumonji domain containing 2A; Jumonji domain-containing protein 2A; lysine (K)-specific demethylase 4A; Lysine-specific demethylase 4A; tudor domain containing 14A
Gene Aliases: JHDM3A; JMJD2; JMJD2A; KDM4A; KIAA0677; TDRD14A
UniProt ID: (Human) O75164
Entrez Gene ID: (Human) 9682, (Rat) 313539
Molecular Function:
histone modifying enzyme
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