Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
JMJD2C is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma.
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Protein Aliases: bA146B14.1; GASC-1 protein; GASC1; gene amplified in squamous cell carcinoma 1; Gene amplified in squamous cell carcinoma 1 protein; JHDM3C; JmjC domain-containing histone demethylation protein 3C; JMJD2C; jumonji domain containing 2C; Jumonji domain-containing protein 2C; lysine (K)-specific demethylase 4C; Lysine-specific demethylase 4C; RP11-169L18.1; tudor domain containing 14C
Gene Aliases: 2410141F18Rik; AA517467; GASC1; JHDM3C; JMJD2C; KDM4C; KIAA0780; TDRD14C