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Invitrogen
JMJD4 Polyclonal Antibody
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Product Details
PA5-96889
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-463 of human JMJD4 (NP_0753832)
Conjugate
Form
Liquid
Concentration
1.86 mg/mL
Amount
186 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MRAGPEPQAL AGQKRGALRL LVPRLVLTVS APAEVRRRVL RPVLSWMDRE TRALADSHFR GLGVDVPGVG QAPGRVAFVS EPGAFSYADF VRGFLLPNLP CVFSSAFTQG WGSRRRWVTP AGRPDFDHLL RTYGDVVVPV ANCGVQEYNS NPKEHMTLRD YITYWKEYIQ AGYSSPRGCL YLKDWHLCRD FPVEDVFTLP VYFSSDWLNE FWDALDVDDY RFVYAGPAGS WSPFHADIFR SFSWSVNVCG RKKWLLFPPG QEEALRDRHG NLPYDVTSPA LCDTHLHPRN QLAGPPLEIT QEAGEMVFVP SGWHHQVHNL DDTISINHNW VNGFNLANMW RFLQQELCAV QEEVSEWRDS MPDWHHHCQV IMRSCSGINF EEFYHFLKVI AEKRLLVLRE AAAEDGAGLG FEQAAFDVGR ITEVLASLVA HPDFQRVDTS AFSPQPKELL QQLREAVDAA AAP; Positive Samples: 293T, HepG2, NCI-H460, BT-474, MCF7, Mouse liver, Mouse brain, Rat liver
Target Information
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2-oxoglutarate and iron-dependent oxygenase JMJD4; 2-oxoglutarate- and Fe(II)-dependent oxygenase; C4 lysyl hydroxylase; JmjC domain-containing protein 4; Jumonji domain-containing protein 4; Lysyl-hydroxylase JMJD4; unnamed protein product
Gene Aliases: 6430559I23; JMJD4; RGD1307186
UniProt ID: (Human) Q9H9V9, (Mouse) Q8BFT6
Entrez Gene ID: (Human) 65094, (Rat) 287359, (Mouse) 194952
protein binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
sequence-specific DNA binding
metal ion binding
dioxygenase activity
peptidyl-lysine 4-dioxygenase activity
catalytic activity, acting on a protein
molecular_function
protein modifying enzyme
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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