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JMJD6 Polyclonal Antibody

View all (9) JMJD6 antibodies

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JMJD6 Polyclonal Antibody

Product Details

600-401-CC1

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

2.5 µg/mL
-

Immunocytochemistry (ICC/IF)

2.5 µg/mL
-

ELISA (ELISA)

1:10,000-1:20,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Anti-JMJD6 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide from near the N-terminus of human JMJD6.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: apoptotic cell clearance receptor PtdSerR; arginine demethylase and lysine hydroxylase; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptor; Protein PTDSR; unnamed protein product

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Gene Aliases: 5730436I23Rik; D11Ertd195e; JMJD6; KIAA0585; mKIAA0585; PSR; PtdSerR; PTDSR; PTDSR1

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UniProt ID: (Human) Q6NYC1, (Mouse) Q9ERI5, (Rat) Q6AYK2

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Entrez Gene ID: (Human) 23210, (Mouse) 107817, (Rat) 360665

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Function(s)
RNA binding single-stranded RNA binding iron ion binding protein binding oxidoreductase activity histone demethylase activity histone demethylase activity (H3-R2 specific) histone demethylase activity (H4-R3 specific) oxidative RNA demethylase activity signaling receptor activity identical protein binding metal ion binding dioxygenase activity peptidyl-lysine 5-dioxygenase activity P-TEFb complex binding protein demethylase activity transcription regulator activator activity sulfonate dioxygenase activity receptor activity 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity procollagen-proline dioxygenase activity hypophosphite dioxygenase activity DNA-N1-methyladenine dioxygenase activity C-19 gibberellin 2-beta-dioxygenase activity C-20 gibberellin 2-beta-dioxygenase activity molecular_function protein modifying enzyme
Process(es)
blood vessel development kidney development sprouting angiogenesis chromatin organization chromatin remodeling mRNA processing phagocytosis cell surface receptor signaling pathway heart development RNA splicing peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine cell differentiation lung development negative regulation of protein homooligomerization T cell differentiation in thymus oxidative RNA demethylation macrophage activation apoptotic cell clearance recognition of apoptotic cell positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of mRNA splicing, via spliceosome erythrocyte development protein homooligomerization retina development in camera-type eye membraneless organelle assembly transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development chromatin modification oxidation-reduction process histone H3-R2 demethylation histone H4-R3 demethylation biological_process
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