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Proteintech
JMY Polyclonal Antibody
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Product Details
25098-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
JMY Fusion Protein Ag18735 (712-988 aa encoded by BC130624)
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LRLAHARRK GAASPVLQED HCDSLPSVLQ VEEKTEEVGE GRVKRGPSQT TEPQSLVQLE DTSLTQLEAT SLPLSGVTSE LPPTISLPLL NNNLEPCSVT INPLPSPLPP TPPPLPVAKD SGPETLEKDL PRKEGNEKRI PKSASAPSAH LFDSSQLVSA RKKLRKTAEG LQRRRVSSPM DEVLASLKRG SFHLKKVEQR TLPPFPDEDD SNNILAQIRK GVKLKKVQKD VLRESFTLLP DTDPLTRSIH EALRRIKEAS PESEDEEEAL PCTDWEN (712-988 aa encoded by BC130624 )
Target Information
JMY acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ37870; Junction-mediating and -regulatory protein; junction-mediating and regulatory protein; p300 transcriptional cofactor JMY; similar to junction-mediating and regulatory protein; WAS protein homology region 2 domain containing 1-like 3
Gene Aliases: JMY; WHAMM2; WHDC1L3
UniProt ID: (Human) Q8N9B5, (Mouse) Q9QXM1
Entrez Gene ID: (Human) 133746, (Mouse) 57748, (Rat) 683593
DNA repair
regulation of transcription from RNA polymerase II promoter
cell cycle arrest
Arp2/3 complex-mediated actin nucleation
positive regulation of apoptotic process
positive regulation of sequence-specific DNA binding transcription factor activity
'de novo' actin filament nucleation
actin polymerization-dependent cell motility
regulation of signal transduction by p53 class mediator
cellular response to DNA damage stimulus
regulation of DNA-templated transcription in response to stress
intrinsic apoptotic signaling pathway by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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