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Invitrogen
JNK1 Polyclonal Antibody
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FIGURE: 1 / 10
JNK1 Antibody (44-690G) in IHC (P)
Immunohistochemistry analysis of JNK1 showing staining in the cytoplasm of paraffin-embedded human prostate carcinoma (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature... View More
Product Details
44-690G
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
The antiserum was produced against a chemically synthesized peptide derived from an internal region of JNK1. This region is conserved among human, mouse, and rat forms of JNK1, JNK2, and JNK3 proteins.
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.3, with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
MAPK8 (JNK1) is activated by the presence of misfolded proteins in the endoplasmic reticulum. It is also a crucial mediator of insulin resistance and obesity. It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: c-Jun N-terminal kinase 1; FLJ12099; FLJ33785; JNK-46; JNK1 beta1 protein kinase; JNK3; JNK3A; JUN N-terminal kinase; MAP kinase 10; MAP kinase 8; MAPK 10; MAPK 8; MAPK10; MGC50974; mitogen activated protein kinase 8; Mitogen-activated protein kinase 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; MK10; OTTHUMP00000019552; p493F12; p54 gamma; p54bSAPK; Phospho-JNK; PRKM10; protein kinase JNK1; protein kinase mitogen-activated 8; SAPK gamma; SAPK1c; stress-activated protein kinase 1; Stress-activated protein kinase 1c; Stress-activated protein kinase JNK1
Gene Aliases: AI849689; JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; MAPK8; PRKM8; SAPK1; SAPK1C
UniProt ID: (Human) P45983, (Rat) P49185, (Mouse) Q91Y86
Entrez Gene ID: (Human) 5599, (Rat) 116554, (Mouse) 26419
protein serine/threonine kinase activity
JUN kinase activity
protein binding
ATP binding
kinase activity
enzyme binding
histone deacetylase regulator activity
histone deacetylase binding
nucleotide binding
protein kinase activity
MAP kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein phosphorylation
response to stress
JNK cascade
JUN phosphorylation
response to UV
positive regulation of gene expression
regulation of macroautophagy
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
regulation of histone deacetylation
positive regulation of cyclase activity
negative regulation of protein binding
regulation of protein localization
Fc-epsilon receptor signaling pathway
regulation of circadian rhythm
positive regulation of apoptotic process
negative regulation of apoptotic process
rhythmic process
regulation of sequence-specific DNA binding transcription factor activity
positive regulation of protein metabolic process
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
positive regulation of deacetylase activity
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
ossification
regulation of transcription, DNA-templated
inflammatory response
response to osmotic stress
signal transduction
response to heat
regulation of gene expression
phosphorylation
positive regulation of cell migration
positive regulation of microtubule polymerization
neuron projection development
response to hydrogen peroxide
positive regulation of DNA replication
response to cadmium ion
determination of dorsal identity
cellular response to hydrogen peroxide
cellular response to nitric oxide
type B pancreatic cell apoptotic process
neuronal stem cell population maintenance
programmed necrotic cell death
positive regulation of determination of dorsal identity
positive regulation of apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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