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Invitrogen
JPH3 Polyclonal Antibody
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Product Details
PA5-20644
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid peptide near the center of human JPH3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is Daudi cell lysate.
PA5-20644 can be used with blocking peptide PEP-0764.
Target Information
Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain. In the CNS, both JPH3 and JPH4 are expressed throughout neural sites and contribute to the subsurface cistern formation in neurons. Mice lacking both JPH3 and JPH4 subtypes exhibit serious symptoms such as impaired learning and memory and are accompanied by abnormal nervous functions. A repeat expansion in JPH3 is associated with Huntington disease-like 2. At least two isoforms of JPH3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: JP-3; Junctophilin type 3; Junctophilin-3; trinucleotide repeat containing 22; Trinucleotide repeat-containing gene 22 protein
Gene Aliases: CAGL237; HDL2; JP-3; JP3; JPH3; TNRC22
UniProt ID: (Human) Q8WXH2, (Mouse) Q9ET77
Entrez Gene ID: (Human) 57338, (Mouse) 57340, (Rat) 307916
learning
memory
exploration behavior
locomotion
regulation of neuronal synaptic plasticity
neuromuscular process controlling balance
regulation of ryanodine-sensitive calcium-release channel activity
calcium ion transmembrane transport
release of sequestered calcium ion into cytosol
calcium ion transport into cytosol
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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