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JPH4 Polyclonal Antibody
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FIGURE: 1 / 1
JPH4 Antibody (600-401-CD0) in WB
Western Blot of JPH4 antibody. Lane A: Mouse brain tissue lysate in the absence of blocking peptide. Lane B: Mouse brain tissue lysate in the presence of blocking peptide. Load: 35 µg per lane. Primary Antibody: Anti-JPH4 at 1 µg/mL. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: 65.8 kDa, ~90 kDa for JPH4.
Product Details
600-401-CD0
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-JPH4 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide near the internal region of human JPH4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain. In the CNS, both JPH3 and JPH4 are expressed throughout neural sites and contribute to the subsurface cistern formation in neurons. Mice lacking both JPH3 and JPH4 subtypes exhibit serious symptoms such as impaired learning and memory and are accompanied by abnormal nervous functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: JP-4; jph4 {ECO:0000312|RGD:1303170}; junctophilin like 1; Junctophilin-4; Junctophilin-like 1 protein; type I transmembrane protein; unnamed protein product
Gene Aliases: 9330157P13Rik; JP-4; JP4; JPH4; JPHL1; KIAA1831
UniProt ID: (Human) Q96JJ6, (Mouse) Q80WT0, (Rat) Q69FB3
Entrez Gene ID: (Human) 84502, (Mouse) 319984, (Rat) 445271
learning
regulation of synaptic plasticity
neuromuscular process controlling balance
regulation of cytokine production
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by calcium ion signaling
calcium ion transport into cytosol
regulation of store-operated calcium entry
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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